Hi Carim,
1. Many thanks, again, for your willingness to help, and your time and effort in looking at this.
2. Unfortunately, having -- at your suggestion -- tried both repairing and reinstalling Office 2021, using the Microsoft tools you pointed out, the behaviour remains unchanged, with the problem continuing to manifest itself on my installation.
3. Sometimes just a single click on the orange cell in my demonstration workbook (as well as different cells in other workbooks of similar general structure) will cause a selection of several cells to appear; sometimes it will behave as expected and select just the one intended cell. Using the Shift+PageDown method described in the workbook will always produce an "upwards selection" instead of the expected downwards one.
4. I also tried uploading and converting my demonstration file to Google Sheets, and then exporting it from Sheets as a new, Excel format file, in the hope that that might remove any possible file corruption. But after opening that version in Excel, the problem still remained.
5. Thinking that In case it could possibly be a mouse problem, I also tried an entirely different make and type of mouse (cable connected rather than wireless). But that made no difference either: the problem was still evident. Using the touchpad rather than a mouse usually produced a briefly extended selection which would then revert, by itself, to the single target cell.
6. I suppose it is still possible that this might be mouse-driver-related rather than Excel-related, but I can only use the mouse drivers that are right for my system, so I think that question remains open.
7. I think I'll just have to live with it. Using Ctrl+G to go to the intended cell address is a possible, but cumbersome, workaround.
8. It's clear that other people do encounter this problem, as evidenced by the links below.
a: https://www.quora.com/Why-does…150615&target_type=answer
b: https://www.mrexcel.com/board/…ultiple-cells-bug.693868/
c: https://answers.microsoft.com/…73-452f-ac21-6c8bf19afcfc
To conclude: thank you once again, Carim, for your helpfulness.
Patrick